Baked Cajun Parmesan Salmon is a tasty and easy meal to make during the week! 

Baked Cajun Parmesan Salmon on a sheet pan

Raise your hand if you need a fast yet flavorful weeknight meal?


Well, today, I am making your dinner routine feel like a breeze. I don’t know about you, but I’m always on the struggle bus when it comes to coming up with a weeknight meal. There are only so many nights when you can have roasted chicken and vegetables, am I right? 

The way to get off the struggle bus is with this Baked Cajun Parmesan Salmon. Not only does it take 20 minutes to put together, but the flavor is outstanding. 

Let’s dive in! 

Baked Cajun Parmesan Salmon on a sheet pan

What’s in this  Baked Cajun Parmesan Salmon?

When it comes to making weeknight meals easy you want to use minimal ingredients. Below are just a handful of ingredients you will need to make this baked salmon:

  • Fresh salmon (or you could use frozen and defrost)
  • Unsalted butter
  • Garlic
  • Lemon juice
  • Parsley
  • Cajun seasoning
  • Honey
  • Parmesan 
garlic and butter in a skillet

Tips for Making Baked Cajun Parmesan Salmon

1) Salmon. Try to use the freshest salmon as possible. If you need to defrost frozen salmon the quickest way is to remove the salmon from its packaging and place it into a resealable bag. Push the air out and place the salmon in a large bowl. Place the bowl in your sink under cool running water. If you need to weigh down the salmon to keep it submerged use a canned item. Replace the water every 10 minutes or until the salmon is unfrozen. 

2) Cajun Seasoning. When purchasing store-bought Cajun seasoning make sure it’s salt-free. Many spice companies will add salt to their mixes. By purchasing salt-free you can control the amount of salt in your mixture. Trust me, there’s nothing worse than super salty food! 

3) Par-bake Salmon. By par-baking your salmon you will get a head start not only on cooking the salmon evenly, but it will allow you to add an extra level of flavor before you add the Cajun Parmesan butter. 

garlic and butter being put on salmon

What if I don’t like Salmon?

No problem! I would definitely try halibut, cod, or tilapia! Or if you don’t like fish you can certainly use the same mixture on chicken! 

Do you have to buy the large salmon filet? 

Nope! The best portions to get for salmon are center-cut and weigh about 6 to 8 ounces per person! 

Baked Cajun Parmesan Salmon on a sheet pan

What kind of sides would you serve with this Baked Cajun Parmesan Salmon? 

Options are endless! I would definitely try these brussels sprouts, chickpea salad, or potatoes! 

So, are you ready to jazz up your weeknight meal? I hope you enjoy this recipe because it’s super easy to make and is great for meal prepping too! 

More Easy Weeknight Meals to Make: 

Baked Cajun Parmesan Salmon on a sheet pan

Baked Cajun Parmesan Salmon


  • 1 tbsp olive oil
  • 4 (6 to 8oz) salmon fillets
  • 2 tsp Cajun seasoning, divided
  • salt and pepper to taste
  • 2 tbsp unsalted butter
  • 3 garlic cloves, minced
  • 1 tbsp lemon juice
  • 1 tbsp honey
  • 1 tbsp chopped fresh parsley
  • 2 tbsp grated Parmesan
  • Lemon slices, for garnish


  1. Preheat an oven to 400 degrees. Line a baking sheet with foil and spray with non-stick cooking spray.
  2. Place the salmon fillets on the baking sheet. Drizzle the tops with olive oil, 1 tsp Cajun seasoning, salt, and pepper.
  3. Cook the salmon fillets for about 5 to 6 minutes.
  4. Meanwhile, in a medium skillet melt the butter over medium-high heat. Next, add in the garlic, honey, remaining Cajun seasoning, and Parmesan. Stir to combine and bring the mixture to a simmer. Let the sauce reduce for a few minutes.
  5. Remove the salmon from the oven and cover the salmon fillets with the sauce. Place the salmon back into the oven until cooked through about 10 minutes or until a thermometer reaches 145 degrees.
  6. Serve the salmon with lemon slices!
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Baked Cajun Parmesan Salmon on a sheet pan